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Literature summary extracted from

  • Samanta, A.; Dasgupta, S.; Pathak, T.
    5'-modified pyrimidine nucleosides as inhibitors of ribonuclease A (2011), Bioorg. Med. Chem., 19, 2478-2484.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.18 1-(2,5-dideoxy-5-(4-carboxypiperidinyl)-beta-D-threo-pentofuranosyl)thymine
-
 Bos taurus
4.6.1.18 5'-deoxy-5'-N-(4-carboxypiperidinyl)thymidine
-
 Bos taurus
4.6.1.18 5'-deoxy-5'-N-(4-carboxypiperidinyl)uridine
-
 Bos taurus
4.6.1.18 5'-N-(4-carboxypiperidinyl)-2',3'-didehydro-3',5'-dideoxythymidine
-
 Bos taurus
4.6.1.18 additional information inhibitor synthesis, kinetics, and docking, overview Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus P61823
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 2',3'-cCMP + H2O
-
 Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.18 ribonuclease A
-
 Bos taurus
4.6.1.18 RNase A
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.18 25
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.18 7.5
-
 assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.18 0.075
-
 5'-deoxy-5'-N-(4-carboxypiperidinyl)uridine pH 7.5, 25°C Bos taurus
4.6.1.18 0.162
-
 5'-deoxy-5'-N-(4-carboxypiperidinyl)thymidine pH 7.5, 25°C Bos taurus
4.6.1.18 0.229
-
 1-(2,5-dideoxy-5-(4-carboxypiperidinyl)-beta-D-threo-pentofuranosyl)thymine pH 7.5, 25°C Bos taurus
4.6.1.18 0.25
-
 5'-N-(4-carboxypiperidinyl)-2',3'-didehydro-3',5'-dideoxythymidine pH 7.5, 25°C Bos taurus